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A comparative study of the effect of mouthwashes containing tranexamic acid and nanotrangasemic acid in leukemia patients

A comparative study of the effect of mouthwashes containing tranexamic acid and nanotransexamic acid for controlSpontaneous intraoral bleeding in leukemia patients: A randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230104057046N2
Enrollment
52
Registered
2023-03-12
Start date
2023-03-16
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spontaneous oral bleeding in leukemia patients. Leukemia of unspecified cell type

Interventions

Intervention group The intervention group receives five percent nanotrangasmic acid mouthwash. Each subject will receive 4 containers of 280 ml containing mouthwash. Each patient is taught to use 20 m

Sponsors

Gorgan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Leukemia patients with oral bleeding Patients diagnosed with thrombocytopenia (platelet count less than 20,000 units) Selection of patients with the same frequency of use as assigned random classification Selection of patients with the same interval of chemotherapy

Exclusion criteria

Exclusion criteria: Use of any anti-coagulant or anti-coagulant drugs (such as ASA, NSAID, ...) in the last month Pregnant or nursing mothers Hypersensitivity to tranexamic acid Use of birth control pills Smokers Presence of severe periodontitis The presence of diseases that prohibit the use of anticoagulants

Design outcomes

Primary

MeasureTime frame
The number of times of spontaneous oral bleeding? the presence of spontaneous oral bleeding? the number of bleeding interdental areas after using an interdental toothbrush by the researcher. Timepoint: Measuring the number of bleeding interdental areas before the start of the intervention and 14 days after the start of the intervention? Measuring the number of bleeding times before and after using mouthwash (every day up to two weeks)? Identifying the presence of oral bleeding before and after using mouthwash (every day up to two weeks ). Method of measurement: Evaluation of the presence of bleeding by questionnaire - Evaluation of the number of bleeding areas by the researcher through interdental toothbrushes - Evaluation of the number of bleeding times by questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAliye sensebli

Gorgan University of Medical Sciences

aliyesensebli@gmail.com+98 17 3450 2115

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026