Investigating the effect of combined mouthwash of chlorhexidine, benzydamine, nanosilver and antibiotics in perichronitis patients

Investigating the effect of combined mouthwash of chlorhexidine, benzydamine, nanosilver and antibiotics in improving the amount of pain and maximum opening of the mouth of perichronitis patients: a randomized controlled clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230104057046N1

Enrollment

Registered

2023-03-12

Start date

2023-02-20

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pericoronitis.

Interventions

Intervention 1: Intervention group: The intervention group is provided with a combined mouthwash containing chlorhexidine, benzydamine, nanosilver and antibiotics amoxicillin and metronidazole. Each s

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Acute perichronitis The need to be available during the research process Having informed consent

Exclusion criteria

Exclusion criteria: presence of chronic systemic disease (diabetes, kidney disease) receiving systemic or local antibiotic therapy in the last 3 months chronic perichronitis symptoms of severe perichronitis such as fever (<38.3°C) and facial swelling Periodontal disease in the area of ??perichronitis Smoking Alcohol consumption Pregnancy and breastfeeding Allergy to amoxicillin or non-steroidal anti-inflammatory drugs

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Examining the amount of pain before using mouthwash and on days 1, 2, 3, 4, 5, 6 and 7 after using combined mouthwash compared to chlorhexidine mouthwash in perichronitis patients. Method of measurement: The amount of pain will be measured according to the standard VAS scale on a 100 mm chart.;"Maximum mouth opening of pericroniitis patients". Timepoint: Investigating the amount of maximum mouth opening before using mouthwash and on days 1, 2, 3, 4, 5, 6 and 7 after using combined mouthwash compared to chlorhexidine mouthwash in perichronitis patients. Method of measurement: The maximum amount of mouth opening by a graduated ruler.	—

Measure

Time frame

Pain. Timepoint: Examining the amount of pain before using mouthwash and on days 1, 2, 3, 4, 5, 6 and 7 after using combined mouthwash compared to chlorhexidine mouthwash in perichronitis patients. Method of measurement: The amount of pain will be measured according to the standard VAS scale on a 100 mm chart.;"Maximum mouth opening of pericroniitis patients". Timepoint: Investigating the amount of maximum mouth opening before using mouthwash and on days 1, 2, 3, 4, 5, 6 and 7 after using combined mouthwash compared to chlorhexidine mouthwash in perichronitis patients. Method of measurement: The maximum amount of mouth opening by a graduated ruler.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNeman Arekhi

Gorgan University of Medical Sciences

dr.mortazavi@webmail.goums.ac.ir+98 17 3450 2115

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 6, 2026