Beta thalassemia. Beta thalassemia
Conditions
Interventions
Intervention 1: Intervention group: Children will be given oral iron chelation therapy i.e. daily Deferiprone at a dose of 75mg/kg/day in two to three divided doses, for a period of 6-months. Interven
Sponsors
DHQ Teaching Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 15 Years
Inclusion criteria
Inclusion criteria: Presenting with beta thalassemia major (defined as group of hereditary disorders characterized by a genetic deficiency in the synthesis of beta-globin chains in blood causes severe, transfusion-dependent anemia). Patients who are transfusions dependent with serum ferritin level >2000 ng/ml.
Exclusion criteria
Exclusion criteria: Children already taking trial treatment (as per medical record). Children with liver failure (ALT & AST >50IU). Children having anemia (hemoglobin level <10 g/dl) Children who will lose during follow ups. Parents/Guardian refused the participation of their child. Stoppage of medicine due to side effects/compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum ferritin level. Timepoint: Assessed at baseline and after 6 months of therapy. Method of measurement: Blood sample will be taken by using 3cc disposable syringe and sent to the laboratory of the hospital for assessment of serum ferritin level using standard laboratory protocols. | — |
Countries
Pakistan
Contacts
Public ContactM. Aamir
RESnTEC, Institute of Research
Outcome results
None listed