Haemorrhage from nose, Nosebleed. Epistaxis
Conditions
Interventions
Intervention 1: Intervention group: Tranexamic acid ampule (100 mg/ml) is prepared as a nasal spray and its volume is 5cc given 5 puffs every 12 hours for 3 days. Intervention 2: Control group: Sodium
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: patients with acute spontaneous epistaxis age more than 18 epistaxis is controlled with primary conservative management patient has a consent to enroll the study
Exclusion criteria
Exclusion criteria: sensitivity to tranexamic acid no consent to enroll the study there is any malignancy in the nasopharynx, nasal cavity or sinonasal tract prior packing in nasal cavities when come to ER pregnancy or breastfeeding history of coagulopathies hemodynamic instability second stage of hypertension (SBP>=160 and DBP>=100) epistaxis following trauma history of recent myocardial infarction or stroke renal dysfunction history of thromboembolism or seizure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patients without recurrent epistaxis during 7 days. Timepoint: first day, days 3 and 7 after intervention. Method of measurement: participants statement. | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to control bleeding. Timepoint: minutes to hours after intervention. Method of measurement: physical examination.;Occurrence of side effects during 7 days. Timepoint: 7 days after intervention. Method of measurement: patient statement. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohamadreza Majidi
Mashhad University of Medical Sciences
Outcome results
None listed