corneal ulcer. Corneal ulcer
Conditions
Interventions
Intervention 1: Intervention group: In the first group, the continuation of the routine treatment along with cross-linking (as described in the text) by CXL device (Avedro model from Tovana Radio Equi
@3mw/cm2) which injects 4.5 J/cm2 into the cornea. The steps of the surgical protocol are as follows:1- The patient is covered with a cloth under sterile conditions and the cornea is numbed locally wi
Sponsors
Zahedan University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Every patient with infectious corneal ulcer resistant to routine treatment
Exclusion criteria
Exclusion criteria: Withdrawal from the study during the research for any reason Unwillingness to participate in the study Absence of a regular clinical record History or presence of previous eye disease Systemic diseases have been proven to be effective in the treatment process, such as diabetes, autoimmune diseases, etc. Impossibility of patient follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Average size and area of the wound. Timepoint: Measurement of the average size and area of the wound before treatment, one day, three days, one week, 14 days, 21 days and 28 days after treatment. Method of measurement: slit-lamp device in two axes (the largest size and the smallest size).;Frequency of stromal infiltration in corneal ulcer. Timepoint: Frequency of stromal infiltration before treatment, one day, three days, one week, 14 days, 21 days, 28 days after treatment. Method of measurement: slit-lamp device (from +4 to +1).;Frequency of blunting of wound edges. Timepoint: Frequency of blunting of wound edges before treatment, one day, three days, one week, 14 days, 21 days, 28 days after treatment. Method of measurement: Slit-lamp device +1 to +4.;Recovery time. Timepoint: Recovery time before treatment, one day, three days, one week, 14 days, 21 days, 28 days after treatment. Method of measurement: From the patient's file.;Frequency of wound penetration. Timepoint: Frequency of wound penetration before treatment, one day, three days, one week, 14 days, 21 days, 28 days after treatment. Method of measurement: slit-lamp device (grade one: limited to the anterior 1/3 of the cornea, grade two: limited to the anterior 2/3 of the cornea, grade three: involvement of the entire thickness of the cornea). | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of pain. Timepoint: Frequency of pain before treatment, one day, three days, one week, 14 days, 21 days, 28 days after treatment. Method of measurement: Questionnaire yes or no.;Frequency of visual acuity. Timepoint: Frequency of visual acuity before treatment, one day, three days, one week, 14 days, 21 days, 28 days after treatment. Method of measurement: With questions and pen light: non-understanding of light (NLP), understanding of light (LP), understanding of hand movements (HM), counting fingers (CF) in meters.;Vascularization frequency. Timepoint: Frequency of vascularization before treatment, one day, three days, one week, 14 days, 21 days, 28 days after treatment. Method of measurement: slit-lamp device (yes/no).;Average hypopyon size. Timepoint: Average hypopyon size before treatment, one day, three days, one week, 14 days, 21 days, 28 days after treatment. Method of measurement: slit-lamp device (mm). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSoroush Jamshidian
Zahedan University of Medical Sciences
Outcome results
None listed