Knee osteoarthritis. Unilateral primary osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: During the surgery and before prosthesis placement, patients in intervention group receive treatment by injecting a cocktail mixture of 10 cc Marcaine 5% and two am
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients with knee osteoarthritis indicated to undergo unilateral primary Total Knee Arthroplasty (TKA ) Between 18 to 80 years Informed consent to participate in this study Preoperative American Society of Anesthesiologists (ASA) classification ranging from I to III, indicating low to moderate risk before the surgery
Exclusion criteria
Exclusion criteria: Not consent to participate in the study Revision TKA Bilateral TKA Substance abuse (drugs/alcohol) Active gastrointestinal ulcer Individuals diagnosed with rheumatoid arthritis Corticosteroid use in the three months prior to surgery Steroid sensitivity Patients with cancer, heart diseases, kidney failure, diabetic neuropathy, rheumatoid arthritis, neurological or psychiatric disorders impacting pain perception Immunocompromised patients Pregnant women Age under 18 years old
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity. Timepoint: Before surgery, and then at one week, two weeks, four weeks, twelve weeks, and twenty-four weeks after surgery. Method of measurement: Pain score using Visual analogue scale (VAS), a 10-point visualization scale.;Knee function. Timepoint: Before surgery, and then at one week, two weeks, four weeks, twelve weeks, and twenty-four weeks after surgery. Method of measurement: The scoring questionnaires specific to knee joint replacement surgery include KSS (Knee Society Score) and Oxford score. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mohammad Hossein Ebrahimzadeh
Mashhad University of Medical Sciences
Outcome results
None listed