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Dextromethorphan augmentation therapy for obsessive compulsive disorder

Dextromethorphan augmentation therapy for moderate-to-severe obsessive–compulsive disorder: randomized, double-blind,placebo-controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221227056943N1
Enrollment
54
Registered
2023-01-16
Start date
2023-01-20
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obsessive compulsive disorder. Obsessive-compulsive disorder

Interventions

Intervention 1: Intervention group: one tablet of dextromethorphan with a dose of 15 mg BID daily are given orally along with the previously used SSRI drug for 90 days from Dana Pharmaceutical Company

Sponsors

Zanjan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients diagnosed with obsessive-compulsive disorder with moderate to high severity (YBOCS>16) Patients who have not responded to 12 weeks of obsessive-compulsive disorder treatment with an adequate dose of an SSRI People over 18 years old People who have filled out informed consent

Exclusion criteria

Exclusion criteria: Comorbidity with other psychiatric disorders except major depressive disorder, including psychotic disorders, substance dependence disorders Pregnancy Severe kidney and liver disease Unstable medical condition

Design outcomes

Primary

MeasureTime frame
Severity of Obsessive Compulsive Disorder based on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Timepoint: Yale-Brown obsessive compulsive scale (Y-BOCS) was measured at the beginning of the study and 30 and 90 days after the start of treatment. Method of measurement: Yale-Brown obsessive compulsive scale (Y-BOCS) Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRomina Bagheri

Zanjan University of Medical Sciences

Romina.bagheri.s@gmail.com+98 28 3336 8142

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026