Effect of safflower honey-based topical product in treatment of vitiligo

Comparison of the Effectiveness of safflower honey-based topical product with tacrolimus on improvement of symptoms (whiteness size and color) in vitiligo patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221226056928N1

Enrollment

Registered

2023-01-23

Start date

2023-05-22

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vitiligo. Vitiligo

Interventions

Intervention 1: Intervention group: Applying a thin layer of honey-based safflower topical product to the affected area twice a day. Intervention 2: Control group: Applying a thin layer of 0.1% tacrol

Eligibility

Sex/Gender

All

Age

12 Years to 60 Years

Inclusion criteria

Inclusion criteria: Having clear vitiligo lesions with the dermatologist approval Involvement of less than 10% of the body surface

Exclusion criteria

Exclusion criteria: pregnancy or breastfeeding local treatment of vitiligo in the last 4 weeks or systemic treatment or phototherapy in the last 12 weeks progress in the last 6 weeks serious underlying disease or use of immunosuppressive drugs

Design outcomes

Primary

Measure	Time frame
The extent of vitiligo lesions. Timepoint: Measuring the extent of vitiligo lesions at the beginning of the study (before the start of the intervention) and 28 and 84 days after the start of using the honey-based safflower topical product. Method of measurement: Calculating the area of the lesion using transparent graded paper.;Color index of vitiligo lesions. Timepoint: Measurement of the color index of vitiligo lesions at the beginning of the study (before the start of the intervention) and 28 and 84 days after the start of the use of honey-based safflower topical product. Method of measurement: Comparison of whitening rate with healthy skin, (completely white 100%; slightly colored white 90%; whiteness more than colored 75%; Whiteness and colored equal to 50%; Whiteness less than colored 75%; brief whiteness 10%; Natural skin color%0) by observation and photography.;Vitiligo Area Scoring Index (VASI). Timepoint: Measurement of the Vitiligo Area Scoring Index (VASI) at the beginning of the study (before the start of the intervention) and 28 and 84 days after the start of using the honey-based safflower topical product. Method of measurement: We multiply the color index of each lesion by the percentage of involvement of each lesion compared to the whole skin of the body and add up the obtained numbers.;Quality of life score in VitiQoL questionnaire. Timepoint: Fill out vitiligo quality of life questionnaire at the beginning of the study (before the start of the intervention) and 84 days after starting the use of honey-based safflower topical product. Method of measurement: Vitiligo quality of life questionnaire (VitiQoL).	—

Measure

Time frame

The extent of vitiligo lesions. Timepoint: Measuring the extent of vitiligo lesions at the beginning of the study (before the start of the intervention) and 28 and 84 days after the start of using the honey-based safflower topical product. Method of measurement: Calculating the area of the lesion using transparent graded paper.;Color index of vitiligo lesions. Timepoint: Measurement of the color index of vitiligo lesions at the beginning of the study (before the start of the intervention) and 28 and 84 days after the start of the use of honey-based safflower topical product. Method of measurement: Comparison of whitening rate with healthy skin, (completely white 100%; slightly colored white 90%; whiteness more than colored 75%; Whiteness and colored equal to 50%; Whiteness less than colored 75%; brief whiteness 10%; Natural skin color%0) by observation and photography.;Vitiligo Area Scoring Index (VASI). Timepoint: Measurement of the Vitiligo Area Scoring Index (VASI) at the beginning of the study (before the start of the intervention) and 28 and 84 days after the start of using the honey-based safflower topical product. Method of measurement: We multiply the color index of each lesion by the percentage of involvement of each lesion compared to the whole skin of the body and add up the obtained numbers.;Quality of life score in VitiQoL questionnaire. Timepoint: Fill out vitiligo quality of life questionnaire at the beginning of the study (before the start of the intervention) and 84 days after starting the use of honey-based safflower topical product. Method of measurement: Vitiligo quality of life questionnaire (VitiQoL).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Najjarzadeh

Shahed University

dmrnajjarzadeh@gmail.com+98 21 7773 4834

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026