Investigating the effect of mouthwash containing an acidophilic strain of Lactobacillus brevis enriched with selenium on the microbial flora of the gastrointestinal tract and the healing of oral ulcers in ICU patients of Shahid Bahonar Medical Center, Kerman.

Investigating the effect of mouthwash containing an acidophilic strain of Lactobacillus brevis enriched with selenium on the microbial flora of the gastrointestinal tract and the healing of oral ulcers in ICU patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221221056887N1

Enrollment

Registered

2023-03-06

Start date

2023-04-21

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: oral ulcer. Condition 2: Changing the flora of the digestive tract. Other forms of stomatitis Infectious gastroenteritis and colitis, unspecified

Interventions

Intervention 1: Intervention group: The studied mouthwash (produced in Kerman University of Medical Sciences, Iran, where Lactobacillus isolated from dairy and edible products is cultured in an enviro

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Being hospitalized in the ICU department of Bahnar Hospital No sepsis, pneumonia, or other active infection No known immunodeficiency For intubated patients, cases that the intubation tube is cuffed are selected

Exclusion criteria

Exclusion criteria: The patient was discharged from the ICU and anesthesia service of Bahnar Hospital

Design outcomes

Primary

Measure	Time frame
Oral ulcer. Timepoint: The entire duration of drug administration. Method of measurement: Observation and examination of the wound by the researcher(wound healing time AND Wound dimensions).;Gastrointestinal flora. Timepoint: The beginning and the end of the study and according to the routine of the department. Method of measurement: The information available in the system and the response section of the patient's tests(Microbial flora of the pharynx).	—

Measure

Time frame

Oral ulcer. Timepoint: The entire duration of drug administration. Method of measurement: Observation and examination of the wound by the researcher(wound healing time AND Wound dimensions).;Gastrointestinal flora. Timepoint: The beginning and the end of the study and according to the routine of the department. Method of measurement: The information available in the system and the response section of the patient's tests(Microbial flora of the pharynx).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarshid Ataollahi

Kerman University of Medical Sciences

farshid.ataollahi@gmail.com+98 34 3223 8942

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026