Prediabetes. Impaired glucose tolerance (oral)
Conditions
Interventions
Intervention 1: Intervention group: Red beetroot powder prepared by Pak Shilan Negin Salamat private company located in Chaharmahal and Bakhtiari province, producing all kinds of fruit powder, summer
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age 20-80 years old BMI 18-35 kg/m2
Exclusion criteria
Exclusion criteria: People with type 1, type 2, or gestational diabetes mellitus Use of any anti-diabetic agent except metformin Taking medication that affects glucose metabolism such as glucocorticoids, less than eight weeks before the start of the study Receiving growth hormone in less than six months before the start of the study Allergy to beetroot consumption A smoker or a history of smoking and alcohol consumption in the previous two years History of cardiovascular diseases (open heart surgery, cardiac congestion, heart failure, and uncontrolled blood pressure), liver cirrhosis/liver transplant, and/or kidney disease (CKD) History of inflammatory diseases such as rheumatoid arthritis A history of hypothyroidism or hyperthyroidism History of suffering from severe digestive diseases or mental illnesses Having often physical activity (more than 5 hours a week) Taking antioxidant supplements or hormonal treatments 4 weeks before the study Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 2-hour blood glucose. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method.;Fasting blood sugar. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method.;Fasting insulin. Timepoint: At the baseline and after 12 weeks. Method of measurement: The enzyme-linked immunosorbent assay.;Hemoglobin A1C. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method.;Homeostatic model assessment for insulin resistance. Timepoint: At the baseline and after 12 weeks. Method of measurement: Calculated by formula.;The quantitative insulin-sensitivity check index. Timepoint: At the baseline and after 12 weeks. Method of measurement: Calculated by formula. | — |
Secondary
| Measure | Time frame |
|---|---|
| Glutathione. Timepoint: At the baseline and after 12 weeks. Method of measurement: The enzyme-linked immunosorbent assay.;Total antioxidant capacity. Timepoint: At the baseline and after 12 weeks. Method of measurement: The enzyme-linked immunosorbent assay.;Total oxidative stress. Timepoint: At the baseline and after 12 weeks. Method of measurement: The enzyme-linked immunosorbent assay.;Alanine transaminase. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method.;Aspartate aminotransferase. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method.;Alkaline Phosphatase. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method.;Gamma-glutamyltransferase. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method.;The Fibrosis-4 score. Timepoint: At the baseline and after 12 weeks. Method of measurement: Calculated by formula.;Serum creatinine. Timepoint: At the baseline and after 12 weeks. Method of measurement: Kinetic Jaffe calorimetry.;Urine creatinine. Timepoint: At the baseline and after 12 weeks. Method of measurement: Kinetic Jaffe calorimetry.;Blood urea nitrogen. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method.;Urine microalbumin. Timepoint: At the baseline and after 12 weeks. Method of measurement: The enzyme-linked immunosorbent assay.;Triglyceride. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method.;Total cholesterol. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method.;Low density lipoprotein. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method.;High density lipoprotein. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method.;High sensitivity-C Reactive Protein. Timepoint: At the ba | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElham Hosseini
Esfahan University of Medical Sciences
Outcome results
None listed