the effect of vitamin K supplementation on bone factors in hemodialysis patients

Investigating the effect of vitamin K supplementation on bone factors in hemodialysis patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221217056845N1

Enrollment

Registered

2023-03-04

Start date

2023-01-05

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with ESRD undergoing hemodialysis. Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease

Interventions

Intervention 1: Intervention group: Calcium-D capsule (Shefa company contains 500 mg calcium and 200 IU vitamin D) along with vitamin K2 tablets (capsule containing vitamin K2-7, microcrystalline, cel

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Not using anticoagulant drugs age 18-75 years patient with ESRD and hemodialysis patients that dialyses > 1 months.

Exclusion criteria

Exclusion criteria: Coagulation disorder Lack of consent to study Hypocalcemia or hypercalcemia in patients Infection before and during treatment with High CRP Using of antibiotic drugs Using of osteoporosis drugs lack of medication compliance

Design outcomes

Primary

Measure	Time frame
Comparison of the average serum levels of albumin after the implementation of the intervention. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.;Comparison of the average serum levels of calcium after the implementation of the intervention. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.;Comparison of the average serum levels of phosphorus after the implementation of the intervention. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.;Comparison of the average serum levels of Vitamin D after the implementation of the intervention. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.	—

Measure

Time frame

Comparison of the average serum levels of albumin after the implementation of the intervention. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.;Comparison of the average serum levels of calcium after the implementation of the intervention. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.;Comparison of the average serum levels of phosphorus after the implementation of the intervention. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.;Comparison of the average serum levels of Vitamin D after the implementation of the intervention. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.

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Secondary

Measure	Time frame
Comparison of the mean serum PTH level after the implementation of the intervention to the basic value. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.;Comparison of the mean serum alkaline phosphatase (AKP) level after the implementation of the intervention to the basic value. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.	—

Measure

Time frame

Comparison of the mean serum PTH level after the implementation of the intervention to the basic value. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.;Comparison of the mean serum alkaline phosphatase (AKP) level after the implementation of the intervention to the basic value. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSedighe Maghsoudloo

Gorgan University of Medical Sciences

roya_sissy200@yahoo.com+98 17 3246 0722

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026