Investigating the effect of aspiration with and without Tranexamic acid and Lidocaine injection in Hemophilia patients with knee hemarthrosis

Comparison of the effectiveness of aspiration with and without intra-articular injection of Tranexamic acid and Lidocaine in adult Hemophilia patients with acute hemarthrosis of the knee joint in the first 24 hours

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221216056838N1

Enrollment

Registered

2023-02-28

Start date

2023-03-11

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemophilia. Other disorders of blood and blood-forming organs in diseases classified elsewhere

Interventions

Intervention 1: Intervention group: Hemophilia patients with acute hemarthrosis of the knee (first 24 hours) who refer to Imam Khomeini Hospital undergo an ultrasound examination to confirm hemarthros

tranexamic acid: The safe dose for intra-articular injection of tranexamic acid is 20 mg/ml. 1.5 g tranexamic acid in 75 ml of normal saline serum was injected intra-articularly. Note that the same ph

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Hemophilia patients with acute hemarthrosis of the knee joint in the first 24 hours

Exclusion criteria

Exclusion criteria: Blood clots in the joint slight bleeding patient dissatisfaction joint fluid infection history of seizures and heart diseases G6PD history of DVT

Design outcomes

Primary

Measure	Time frame
Range of Motion. Timepoint: 3 Days, aweek later, weekly until complete healing of hemarthrosis. Method of measurement: Using a Protractor.;Type of Hemophilia. Timepoint: Before entering the study. Method of measurement: Using the patient's hemophilia file.;Severity of Hemophilia. Timepoint: Before entering the study. Method of measurement: Using the patient's hemophilia file.;The amount of pain. Timepoint: 3 Days, a week later, weekly until complete healing of hemarthrosis. Method of measurement: Vas score.;Back to Work and School day. Timepoint: Every day until returning to work. Method of measurement: Questionnaire.;Coagulation factor dose. Timepoint: Until receiving the coagulation factor. Method of measurement: Patient's hospitalization file.;How long it takes to end the pain. Timepoint: Every day until the end of the pain. Method of measurement: Questionnaire.	—

Measure

Time frame

Range of Motion. Timepoint: 3 Days, aweek later, weekly until complete healing of hemarthrosis. Method of measurement: Using a Protractor.;Type of Hemophilia. Timepoint: Before entering the study. Method of measurement: Using the patient's hemophilia file.;Severity of Hemophilia. Timepoint: Before entering the study. Method of measurement: Using the patient's hemophilia file.;The amount of pain. Timepoint: 3 Days, a week later, weekly until complete healing of hemarthrosis. Method of measurement: Vas score.;Back to Work and School day. Timepoint: Every day until returning to work. Method of measurement: Questionnaire.;Coagulation factor dose. Timepoint: Until receiving the coagulation factor. Method of measurement: Patient's hospitalization file.;How long it takes to end the pain. Timepoint: Every day until the end of the pain. Method of measurement: Questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Hadi Kalantar

Tehran University of Medical Sciences

hadikalantar4@gmail.com+98 912 611 0015

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026