The effectiveness of probiotics in eradicating Helicobacter pylori infection of the stomach

A clinical trial comparing the effectiveness of probiotics along with standard three drug treatment and standard three drug treatment alone in eradicating Helicobacter pylori in dyspeptic patients between 15 and 45 years old with positive fecal antigen

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221216056834N1

Enrollment

200

Registered

2023-02-02

Start date

2023-02-20

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori infection in dyspeptic patients. Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere

Interventions

Intervention 1: Control group: allocation of the standard treatment regimen alone (i.e. pentaprazole 40 mg (b.i.d), amoxicillin 1000 mg (b.i.d), clarithromycin 500 mg (b.i.d)) for 14 days along with a

Eligibility

Sex/Gender

All

Age

15 Years to 45 Years

Inclusion criteria

Inclusion criteria: age between 15-40 years Verbal and written consent symptoms of dyspepsia Positive fecal Helicobacter pylori antigen test.

Exclusion criteria

Exclusion criteria: use of any antibiotic in the last 2 weeks consumption of pump inhibitor during the last 1 month History of any proven malignancy history of receiving Helicobacter pylori eradication regimen at any time in the past.

Design outcomes

Primary

Measure	Time frame
Fecal antigen. Timepoint: one month after the end of the intervention. Method of measurement: elisa test.	—

Secondary

Measure	Time frame
Digestive complications. Timepoint: 1 month after the end of the intervention. Method of measurement: questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRamin Talaie

Shahid Beheshti University of Medical Sciences

r.talaie@sbmu.ac.ir021_23515

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026