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Using growth factor to prepare the implant area

Clinical and histologicalevaluation of socket preservation using concentrated growth factor for implant site preparation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221216056831N1
Enrollment
45
Registered
2022-12-28
Start date
2022-12-18
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental implant. Presence of tooth-root and mandibular implants

Interventions

Intervention 1: Intervention group: In order to obtain concentrated growth factor, on the day of surgery, a 9 cc venous blood sample was taken from the patients and this sample will be centrifuged (Me
Silfradent®Srl, S. Sofia (FC), Italy) at a speed of 2400 to 2700 rpm. After tooth extraction, using a probe, the maximum socket diameter will be measured in both mesiodistal and palatal/lingual vestib

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Implant candidate patients in the area of extracted teeth At least 18 years old No systemic problems

Exclusion criteria

Exclusion criteria: Smokers with more than 10 cigarettes per day Patients with allergies to any of the substances used in this study Patients undergoing head or neck radiation therapy or chemotherapy in the 12 months prior to surgery Pregnant or lactating patients

Design outcomes

Primary

MeasureTime frame
Changes in mesiodistal (MD) and vestibulo-palatal/lingual (VP/L) dimensions. Timepoint: 2 months after the operation. Method of measurement: The maximum diameter of the socket is measured using the William probe and recorded in both the mesiodistal and vestibulo-lingual/palatal dimensions at the crestal level.;The amount of pain. Timepoint: During 7 days after the operation. Method of measurement: Visual Analogue Scale.;Soft tissue quality. Timepoint: 7 days after extraction. Method of measurement: The quality of the soft tissue of the surgical area (tissue color, tissue consistency, pus secretion, bleeding) will be evaluated through a modified version of Landry, Turnbull and Howley's Healing Index (HI).

Secondary

MeasureTime frame
Histomorphological factors. Timepoint: After 2 months. Method of measurement: A sample will be taken from Saket for histological evaluation. After fixation and decalcification, the samples will be stained with hematoxylin and eosin (H&E) and histomorphological factors (percentage of remaining scaffold, bone and connective tissue) will be evaluated.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoumeh Faramarzi

Tabriz University of Medical Sciences

m.faramarzi@tbzmed.ac.ir+98 44 3344 4598

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026