Ulcerative Colitis Inflammation. Ulcerative colitis
Conditions
Interventions
Intervention 1: Intervention group: Sodium Butyrate 600 mg/day. Intervention 2: Control group: Starch 600 mg/day.
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Male or female 18 to 60 years old Body mass index between 18.5 and 30 Estimating the severity of the disease based on the Mayo The severity of the disease is mild to moderate Patients with ulcerative colitis diagnosed by colonoscopy Informed consent from the patient Patients who are in the quiescent stage of the disease are included in the study, and patients who are in the acute stage of the disease are excluded. The patient should refrain from any self treatment and use of herbal medicines.
Exclusion criteria
Exclusion criteria: Patients with other gastrointestinal diseases including intestinal obstruction, fistula, celiac disease, cancer and infectious diseases Pregnancy and breastfeeding Use of antibiotic drugs and other probiotic products and vitamin and mineral supplements for the previous 2 months. History of hospitalization in the last 3 months Type 2 diabetes patients Acute stage of the disease Change in the process of drug consumption during the study Intensification of the disease during study The place of implementation of the study is Faqihi Hospital and Motahari Clinic of Shiraz University of Medical Sciences
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in gene Sirt1 expression. Timepoint: At the beginning of the study and 3 months later (the end of the study). Method of measurement: Real time PCR. | — |
Secondary
| Measure | Time frame |
|---|---|
| Life quality score. Timepoint: At the beginning of the study and 3 months later (the end of the study). Method of measurement: IBDQ9 questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Vatanpour
Shiraz University of Medical Sciences
Outcome results
None listed