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effectiveness of transcranial direct current stimulation and varenicline on, excutive function, cravings and,depression, anxiety and stress in smokers with major depressive disorder

Comparison and Combination the effectiveness of transcranial direct current stimulation and varenicline on excutive function, cravings, depression, anxiety and stress in smokers with major depressive disorder

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221214056816N1
Enrollment
100
Registered
2023-02-12
Start date
2023-02-05
Completion date
Unknown
Last updated
2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

People with smoking. Tobacco use

Interventions

Intervention 1: Intervention group: common protocol to reduce cravings in smokers through extracranial stimulation device (tDCS), placing the stimulating electrode (anode) on the right dorsolateral pr

Sponsors

Zanjan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Having the ability to give informed consent to participate in research Being at least 18 and at most 65 years old Daily consumption of more than ten cigarettes for at least two years(14) Non-use of other substances such as: methamphetamine, opioid and benzodiazepine (specified through clinical interview by Ballinger) Having a diagnosis of major depression Failure to consider other severe psychiatric disorders that will be screened through the structured interview of SKID

Exclusion criteria

Exclusion criteria: Consuming more than one marijuana cigarette per week Having a history of neurological diseases such as Parkinson's, epilepsy, convulsions, strokes and cardiovascular problems Having diseases related to the scalp Having a history of head trauma Presence of a device or tool in the head Exiting from the research after absence In two continuous sessions of treatment Pregnancy or breastfeeding

Design outcomes

Primary

MeasureTime frame
Decreasing score in depression, anxiety, stress Scale(DASS). Timepoint: 3 Month. Method of measurement: Dass questionnaire.;Decreasing score in mood profile. Timepoint: 3 Month. Method of measurement: mood profile questionnaire.;Decreasing score in craving questionnaire. Timepoint: 3 Month. Method of measurement: craving questionnaire.;Improving inhibition in Stroop test. Timepoint: 3 Month. Method of measurement: Stroop software.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEskandari Zakaria

Zanjan University of Medical Sciences

eskandari.psychology@gmail.com+98 24 3354 4001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026