The effect of oral probiotic(LactoCare) on psoriasis patients

Evaluation of the effect of oral probiotics on population, receptor expression, and related cytokines of T and B cells subsets in psoriasis patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221213056802N1

Enrollment

Registered

2023-03-01

Start date

2023-04-19

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Psoriasis. Psoriasis vulgaris

Interventions

Intervention 1: Intervention group: patients are instructed to consume orally one LactoCare probiotic tablet(zist takhmir, Iran) daily for 3 months. Intervention 2: Control group: patients are instruc

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 65 years Signing the informed consent form Patients with the diagnosis of the moderate to severe psoriasis based on Psoriasis Area and Severity Index( PASI score)

Exclusion criteria

Exclusion criteria: Pregnant or lactation Suffering from other autoimmune disease and inflammation disease Suffering from cirrhosis and hepatic disease Suffering from metabolic syndrome Suffering from severe renal disease The consumption of antibiotics and any kind of probiotics 2 weeks ago Worsening of signs and symptoms of psoriasis during treatment

Design outcomes

Primary

Measure	Time frame
The population of TH1. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.;The population of TH2. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.;The population of Treg. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.;The population of B cells. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.;The population of TH17. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.	—

Measure

Time frame

The population of TH1. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.;The population of TH2. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.;The population of Treg. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.;The population of B cells. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.;The population of TH17. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHanieh Kolahdooz Ghuchani

Mashhad University of Medical Sciences

Haniz93@rocketmail.com009838691760

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026