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The effect of antibiotic prophylaxis on wound healing in smokers after implant surgery.

Evaluation of the effect of antibiotic prophylaxis on postoperative wound healing of smoking patients undergoing implant surgery in patients

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221212056786N5
Enrollment
50
Registered
2025-09-23
Start date
2025-09-23
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Studying the effect of antibiotic prophylaxis on wound healing in smoking patients.

Interventions

Intervention 1: Intervention group: Group 1: 2 grams of amoxicillin preoperatively, 1 hour before implant placement, and 500 mg three times a day (8 hours) on days 2 and 3.Articaine 4% (Darupaksh, Teh

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
19 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with good general health status (ASA class 1 or 2) Are over 19 years old Patients who smoke 11 to 19 cigarettes per day They are not allergic to penicillin or amoxicillin antibiotics. Absence of local infection in other areas of the patient's mouth Has an edentulous space in the upper or lower jaw with normal alveolar bone Patients who do not use nutritional supplements People who have not used any antibiotics in the past 3 months Pregnant women, women planning to become pregnant, and breastfeeding women should be excluded from the study the patients who are candidates for implant

Exclusion criteria

Exclusion criteria: Patients with good general health status (ASA class 3 and above) Patients are candidates for multiple implants in different areas and as fresh socket Non-smoking patients Patients with a history of taking antibiotics and medications that interfere with wound healing Patients who use nutritional supplements Pregnant women and those planning to become pregnant Uncooperative patients Patients with a history of alcohol use

Design outcomes

Primary

MeasureTime frame
Wound healing index. Timepoint: In both groups, the measurement time was one week after implant surgery. Method of measurement: Wachtel Index or EHI.;Pain. Timepoint: The VAS scale was measured and recorded on the first, second, fourth, and sixth days in all groups. Method of measurement: Using the VAS criterion.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Mohammad Arab Farashahi

Yazd University of Medical Sciences

sma.farashahi_69@yahoo.com+98 35 3625 5881

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026