postoperative pain. Pain, not elsewhere classified
Conditions
Interventions
Intervention 1: Intervention group 1: pre-operative consumption of one Nobelgin tablet manufactured by Pars Daru Pharmaceuticals, each tablet contains acetaminophen 300 mg, caffeine 15 mg and codeine
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 29 Years
Inclusion criteria
Inclusion criteria: Healthy patients (ASA class I) Candidates of prophylactic removal of mandibular third molar,full or partial bony impaction confirmed by panoramic X-ray Requiring soft tissue flap, bone manipulation and bone removal No medication consumption in the past 21 days The presence of the first and second molars Good oral hygiene Absence of pericoronitis or inflammation signs Absence of local or systemic infection
Exclusion criteria
Exclusion criteria: Smokers Pregnant or breastfeeding women or women of child bearing potential not using adequate contraception Allergy or hypersensitivity to study treatments, rescue medication (rm) or any other nsaids, opioids and acetyl salicylic acid History of NSAID-sensitive asthma History of or the suspicion of drug or alcohol abuse Apical radiolucent image in target tooth Consmuption of central nervous system depressants Pre-existing pain and acute inflammation Inability to understand or perform the study procedure Psychosis Consumption of caffeine-containing beverages, chocolate, or alcohol within 4 hours prior to surgery Oral contraception use Being in the menstrual period Any contraindication of cox-2 inhibitors use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain intensity. Timepoint: 4hours & 7 hours postsurgery,the first day and the third day after surgery. Method of measurement: Visual Analogue Scale.;The time of first analgesic intake. Timepoint: one week after surgery. Method of measurement: Referring to document.;The number of patients who needed analgesics (vas=4). Timepoint: One week after surgery. Method of measurement: Referring to patients' documents.;The total number of analgesics used. Timepoint: One week after surgery. Method of measurement: Referring to patients' documents. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmirhossein Moaddabi
Mazandaran University of Medical Sciences
Outcome results
None listed