Helicobacter pylori infection is a condition in which gram -ve bacteria called H- pylori reside in mucus lining of stomach lead to gastritis, ulcer manifest in the form of dyspepsia. Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention 1: Intervention group: group 2 is the interventional group to which 7-days vonoprazan based triple therapy, new drug regimen, vonoprazn 20mg BD, amoxicillin 1000mg BD, levofloxacin 500mg
Sponsors
National university of Medical Sciences Rawalpindi
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Positive stool antigen test for h-pylori,endoscopic histopathological evidence of h-pylori. Age 18 years and above Both male and female patients presented with symptoms of dyspeps
Exclusion criteria
Exclusion criteria: Patient with history of drug allergy to either Pantoprazole, Vonoprazan Vonoprazan, penicillin’s or clarithromycin , Previous h-pylori eradication therapy, Pregnant and breast-feeding mothers, Patient with serious CVS, liver, renal, pulmonary disorders or acute malignancy, ,History of gastric malignancy or surgery, History of drug abuse. History of using anti-biotics that affect h-pylori with in 4 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Conversion of stool antigen from positive to negative. Timepoint: After 4 weeks after the therapy. Method of measurement: Lab investigation. clinical assessment for symptoms improvement and side effects. | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of clinical symptoms, side effects ,drug compliance,tolerability. Timepoint: 2 and 4 weeks after intervention. Method of measurement: Through telephone and after 4 weeks at hospital OPD. | — |
Countries
Pakistan
Contacts
Public ContactFarzana Waqar
National University of Medical Sciences Rawalpindi
Outcome results
None listed