Critically ill adults admitted to the PICU.
Conditions
Interventions
Intervention 1: Intervention group: 31 patients admitted to the intensive care unit within the first 24 hours of hospitalization were enrolled in the study and will receive 3 vials of 1000 mg L-carnit
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: The patient must be over 18 years old. Critically ill adult patients who are estimated to stay in the ICU for more than 10 days. Legal guardian’s consent for the patient. The patient must be able to tolerate enteral nutrition.
Exclusion criteria
Exclusion criteria: Presence of liver or kidney diseases in which L-carnitine is contraindicated Adult patients undergoing hemodialysis Adult patients undergoing chemotherapy NPO patients for whom initiating enteral nutrition is not feasible Development of gastrointestinal adverse effects following supplement intake
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum C-Reactive Protein (CRP). Timepoint: Before the start of the intervention and 10 days after the start of the intervention. Method of measurement: Immunoturbidimetric Assay. | — |
Secondary
| Measure | Time frame |
|---|---|
| Prognostic Nutritional Index (PNI). Timepoint: Before the start of the intervention and 10 days after the start of the intervention. Method of measurement: The Prognostic Nutritional Index (PNI) will be calculated based on serum albumin concentration and total lymphocyte count, using the following formula: PNI = (10 × serum albumin [g/dL]) + (0.005 × total lymphocyte count [/mm³]).;Prognostic Index. Timepoint: Before the start of the intervention and 10 days after the start of the intervention. Method of measurement: Based on serum C-reactive protein and serum white blood cell count in complete blood count test.;APACHE II Score (Acute Physiology and Chronic Health Evaluation II). Timepoint: Before the start of the intervention and 10 days after the start of the intervention. Method of measurement: Based on physiological indicators, chronic disease history, and clinical scores in 12 vital and laboratory variables.;Serum Albumin. Timepoint: Before the start of the intervention and 10 days after the start of the intervention. Method of measurement: Bromocresol Green (BCG) Assay.;28-day mortality. Timepoint: Before the start of the intervention and 10 days after the start of the intervention. Method of measurement: Medical record review and telephone follow-up.;Nutrition Risk in Critically ill Score (NUTRIC Score). Timepoint: Before the start of the intervention and 10 days after the start of the intervention. Method of measurement: Based on clinical variables including age, APACHE II, SOFA, comorbidities, days from hospital to ICU admission, and IL-6 (if available).;Glasgow Prognostic Score (GCS). Timepoint: Before the start of the intervention and 10 days after the start of the intervention. Method of measurement: Based on C-reactive protein and serum albumin concentrations.;Combined blood count score (CBCS). Timepoint: Before the start of the intervention and 10 days after the start of the intervention. Method of measurement: Based on hematological parameters includi | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Behrooz
Tabriz University of Medical Sciences
Outcome results
None listed