Skin rejuvenation and removal of natural skin pigmentation. Other specified disorders of the skin and subcutaneous tissue related to radiation
Conditions
Interventions
Intervention group: Thirty patients for whom the selected dose of HUCBS will be injected on one side of the face, and on the other side, MN will be combined with the selected dose of HUCBS..
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Having the specified age range Full patient consent for participation in the project No oral collagen consumption No active inflammatory acne (Acne vulgaris) No local infections in the treatment are The skin at the treatment site should not be prone to keloids No malignancies No pregnancy, lactation Not afflicted with clotting or platelet disorders and do not use medications that can affect bleeding or clotting mechanisms No immunosuppression No use of topical and systemic steroids Not afflicted with systemic diseases (high blood pressure, diabetes, heart, kidney and liver diseases) No use of exfoliants 4 weeks prior to treatment No facial botulinum injections due to the potential spread of the toxin No positive history of major surgeries in the past 6 months, No other acute facial viral infections such as herpes simplex, folliculitis No systemic viral infections such as hepatitis B virus (HBV) and HIV
Exclusion criteria
Exclusion criteria: Lack of consent to continue the treatment due to any reason Lack of patient follow-up Severe allergic reaction to the treatment Positive allergic test response to HUCBS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin Elasticity. Timepoint: Beginning of the intervention, two months after the intervention. Method of measurement: Cutometer device.;Skin collagen levels. Timepoint: Beginning of the intervention, two months after the intervention. Method of measurement: Visoface device.;The extent of skin wrinkles. Timepoint: Beginning of the intervention, two months after the intervention. Method of measurement: Visioline device.;Skin moisture content (skin hydration). Timepoint: Beginning of the intervention, two months after the intervention. Method of measurement: Corneometer device.;The extent of skin clarity and brightness. Timepoint: Beginning of the intervention, two months after the intervention. Method of measurement: Colorimeter device.;The skin thickness and density. Timepoint: Beginning of the intervention, two months after the intervention. Method of measurement: Sonography device. | — |
Secondary
| Measure | Time frame |
|---|---|
| The safety and efficacy of treatment. Timepoint: Beginning of the intervention, three consecutive months of intervention, two months after the end of the intervention. Method of measurement: Patient's medical report, form of treatment satisfaction and recovery status that is filled out by the patient. Results from the patient's biometric analysis. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactEhsan Taghiabadi
Tehran University of Medical Sciences
Outcome results
None listed