Characterization and evaluation of the effectiveness of CO2 laser along with human umbilical cord blood serum alginate hydrogel compared to CO2 laser alone in facial skin rejuvenation

Characterization and evaluation of the effectiveness of CO2 laser along with human umbilical cord blood serum alginate hydrogel compared to CO2 laser alone in facial skin rejuvenation (Phase I clinical trial)

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221130056672N8

Enrollment

Registered

2024-04-08

Start date

2024-06-21

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin rejuvenation. Other specified disorders of the skin and subcutaneous tissue related to radiation

Interventions

Intervention 1: Intervention group:A layer of cord blood serum alginate hydrogel is placed on the skin and qualified patients will use it twice a day for two weeks (so that the skin should always be k

Eligibility

Sex/Gender

All

Age

30 Years to 50 Years

Inclusion criteria

Inclusion criteria: Men and women aged 30 to 50 with skin type II to IV who have referred for facial skin rejuvenation in the eye area. People who have not had cosmetic intervention on their face such as botox, dermabrasion, chemical peeling and face lift in the last 6 months.

Exclusion criteria

Exclusion criteria: People who have received oral isotretinoin in the past 6 months and have a history of keloids.

Design outcomes

Primary

Measure	Time frame
Improving repair. Timepoint: All sessions: days 0, 7, 14 and 90. Method of measurement: Skin imaging with Visioface device.;Skin moisture level. Timepoint: All sessions: days 0, 7, 14 and 90. Method of measurement: Corneometer device.;Inflammation and redness. Timepoint: All sessions: days 0, 7, 14 and 90. Method of measurement: Colorimeter and Mexameter Devices.;The amount of skin collagen. Timepoint: Before the CO2 laser, one month and three months later. Method of measurement: Cutometer device.	—

Measure

Time frame

Improving repair. Timepoint: All sessions: days 0, 7, 14 and 90. Method of measurement: Skin imaging with Visioface device.;Skin moisture level. Timepoint: All sessions: days 0, 7, 14 and 90. Method of measurement: Corneometer device.;Inflammation and redness. Timepoint: All sessions: days 0, 7, 14 and 90. Method of measurement: Colorimeter and Mexameter Devices.;The amount of skin collagen. Timepoint: Before the CO2 laser, one month and three months later. Method of measurement: Cutometer device.

—

Secondary

Measure	Time frame
The amount of pain. Timepoint: Days 0, 7, 14 and 90. Method of measurement: Questionnaire survey (Patient self-report).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan Taghiabadi

Tehran University of Medical Sciences

etaghiabadi@sina.tums.ac.ir+98 21 2665 7438

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026