The effect of Trehalose on survival in children

Investigating the effect of Trehalose on survival in children admitted to the intensive care unit

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221129056657N4

Enrollment

170

Registered

2024-11-18

Start date

2024-11-20

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The effect of Trehalose on survival rates in children admitted to the intensive care unit..

Interventions

Intervention 1: Intervention group: Children admitted to the intensive care unit will receive oral Trehalose daily at a dose of 15 gr for 5 days along with a regular diet. Intervention 2: Control grou

Eligibility

Sex/Gender

All

Age

6 Months to 6 Years

Inclusion criteria

Inclusion criteria: Children between the ages of 6 months and 6 years who are hospitalized in the intensive care unit. Completion of the informed consent form by the legal guardian

Exclusion criteria

Exclusion criteria: Children who are transferred to the ICU after surgery.

Design outcomes

Primary

Measure	Time frame
Blood sugar. Timepoint: At least 24 hours after hospitalization and the fifth day of the study. Method of measurement: Using a laboratory kit.;Complete blood count (CBC). Timepoint: At least 24 hours after hospitalization and the fifth day of the study. Method of measurement: Using a laboratory kit.;Blood level of creatinine. Timepoint: At least 24 hours after hospitalization and the fifth day of the study. Method of measurement: Using a laboratory kit.;C reactive protein (CRP). Timepoint: At least 24 hours after hospitalization and the fifth day of the study. Method of measurement: Using a laboratory kit.;Aspartate transferase (AST). Timepoint: At least 24 hours after hospitalization and the fifth day of the study. Method of measurement: Using a laboratory kit.;Alanine transaminase (ALT). Timepoint: At least 24 hours after hospitalization and the fifth day of the study. Method of measurement: Using a laboratory kit.;Prism score. Timepoint: Maximum 4 hours after admission. Method of measurement: Using Prism's checklist and Prism's online score calculator.;Mortality rate. Timepoint: Fifth day of study. Method of measurement: Record in the checklist.	—

Measure

Time frame

Blood sugar. Timepoint: At least 24 hours after hospitalization and the fifth day of the study. Method of measurement: Using a laboratory kit.;Complete blood count (CBC). Timepoint: At least 24 hours after hospitalization and the fifth day of the study. Method of measurement: Using a laboratory kit.;Blood level of creatinine. Timepoint: At least 24 hours after hospitalization and the fifth day of the study. Method of measurement: Using a laboratory kit.;C reactive protein (CRP). Timepoint: At least 24 hours after hospitalization and the fifth day of the study. Method of measurement: Using a laboratory kit.;Aspartate transferase (AST). Timepoint: At least 24 hours after hospitalization and the fifth day of the study. Method of measurement: Using a laboratory kit.;Alanine transaminase (ALT). Timepoint: At least 24 hours after hospitalization and the fifth day of the study. Method of measurement: Using a laboratory kit.;Prism score. Timepoint: Maximum 4 hours after admission. Method of measurement: Using Prism's checklist and Prism's online score calculator.;Mortality rate. Timepoint: Fifth day of study. Method of measurement: Record in the checklist.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactGholamreza Khademi

Mashhad University of Medical Sciences

khademigh@mums.ac.ir+98 51 3189 1780

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026