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Investigating the preventive effect of ethanol and gentamicin in central venous catheter infection

Investigating the preventive effect of gentamicin-lock and ethanol-lock in central venous catheter infection in children admitted to the pediatric intensive care unit.

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221129056657N3
Enrollment
228
Registered
2023-11-14
Start date
2023-11-21
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts. Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts

Interventions

Intervention 1: Intervention group: Gentamicin with a volume of 0.25 cc (10 mg) is mixed with 9.75 cc of normal saline (ideally 1 mg in 1 cc) with a total volume of 10 cc. We inject the contents of th

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Months to 18 Years

Inclusion criteria

Inclusion criteria: Children between the ages of 1 month and 18 years admitted to the pediatric intensive care unit Children undergoing central venous catheter implantation

Exclusion criteria

Exclusion criteria: Hypersensitivity reaction to antibiotics or ethanol that is injected into the line. Any dysfunction of the line occurs after drug injection

Design outcomes

Primary

MeasureTime frame
Prevention of infection (blood culture). Timepoint: Seven days after the start of the intervention. Method of measurement: Bactec automatic blood culture machine.

Secondary

MeasureTime frame
Duration of stay in PICU. Timepoint: The time of discharge of the patient from the intensive care unit. Method of measurement: Use of checklists and patient records.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGholamreza Khademi

Mashhad University of Medical Sciences

khademigh@mums.ac.ir+98 51 3189 1780

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026