The Efficacy of testicular PRP for patients with history of mTESE failure

The Efficacy of Autologous Testicular Platelet Rich Plasma (PRP) for Patients with a History of Microdissection Testicular Sperm Extraction (mTESE) Failure: Clinical Trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221128056644N1

Enrollment

Registered

2023-06-03

Start date

2024-02-20

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-obstructive azoospermia. Azoospermia due to other extratesticular causes

Interventions

Intervention group: Patients with non-obstructive azoospermia have at least one mTESE failure history. After receiving the permission of the ethics committee in the research, the research samples are

Eligibility

Sex/Gender

Male

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Men over 18 years Men with a history of non-obstructive azoospermia and at least one failed mTESE Spouses without any disease related to female infertility

Exclusion criteria

Exclusion criteria: Obstructive azoospermia patients Patients with systemic medical problems Patients with chromosomal disorders

Design outcomes

Primary

Measure	Time frame
Spermatogenesis in non-obstructive azoospermia patients. Timepoint: Semen Analysis before PRP injection and =3 months after PRP injection. Method of measurement: Semen Analysis and Microdissection Testicular Sperm Extraction.	—

Secondary

Measure	Time frame
Determination of fertilization rate. Timepoint: After PRP injection. Method of measurement: Microscopic observations.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarjan Sabbaghian

Royan Institute

marjan.sabbaghian@gmail.com+98 21 2356 2000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026