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The Effect of L-Citrulline and Citrulline Malate Supplementation on Resistance Training Performance

The Effect of Acute and Chronic L-Citrulline and Citrulline Malate Supplementation on Resistance Training Performance, Muscle Soreness, Lactate and Nitric Oxide in Resistance-Trained Men

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221128056642N1
Enrollment
45
Registered
2022-11-29
Start date
2023-02-09
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Resistance training performance.

Interventions

Intervention 1: The first intervention group: supplementation with L-citrulline (8 grams of L-citrulline + 15 grams of maltodextrin) 60 minutes before the start of each main research session (resistan
in the acute phase, a single dose session and in the chronic phase, daily for eight weeks. Intervention 3: Control group: The third group: supplementation with a placebo (15 grams of maltodextrin) 60
in the acute phase, a single dose session and in the chronic phase, daily for eight weeks.

Sponsors

Razi university
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Healthy men living in Kermanshah with an age range between 18 and 35 years History of resistance training at least 3 sessions per week in the last six months Body mass index 18.5 to 29.99 (kg/m2)

Exclusion criteria

Exclusion criteria: Smoking Current or past use of anabolic androgenic steroids Consuming performance-enhancing supplements affecting the research results (including creatine, HMB, beta-alanine and NO stimulants) in the four weeks leading up to the start of the research, or taking L-citrulline or citrulline malate supplements in the past year Suffering from musculoskeletal injuries affecting the process of performing resistance training exercises Having any acute or chronic disease

Design outcomes

Primary

MeasureTime frame
Resistance training performance. Timepoint: Acute phase: three acute research sessions with an interval of one week from each other. Chronic phase: one research session before and one session at the end of the eight-week protocol. Method of measurement: Recording the number of repetitions performed in each set of resistance training - recording the rate of perceived exertion using the Borg scale - measuring muscle soreness using a Visual Analog Scale (VAS) questionnaire.

Secondary

MeasureTime frame
Blood factors (Lactate and Nitric Oxide). Timepoint: Acute phase: three acute research sessions with an interval of one week from each other. Chronic phase: one research session before and one session at the end of the eight-week protocol. Method of measurement: Blood sampling from each subject before and after each main research session.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDavoud Bayat

Razi university

d.bayat@razi.ac.ir+98 83 3838 6074

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 5, 2026