Investigating the effect of total extracts of Lactuca sativa seeds and Melissa officinalis leaves on dental anxiety

Investigating the effect of total extracts of Lactuca sativa seeds and Melissa officinalis leaves on dental anxiety of patients referring for dental extraction; A Randomized Double-blind clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221127056634N2

Enrollment

Registered

2024-10-31

Start date

2024-10-31

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental anxiety.

Interventions

Intervention 1: Intervention group A: Lettuce seed-placebo group: In one session, the patient receives a capsule containing 100 mg of spray-dried total extract powder of Lactuca Sativa seeds (obtained

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 18 years old Patients referred for bilateral extraction of two molar or premolar teeth Having a healthy mental state and the ability and informed consent to complete the questionnaire

Exclusion criteria

Exclusion criteria: Taking CNS depressant and anxiolytic drugs such as benzodiazepines in the past fifteen days Pregnancy or lactation Continuous consumption of Sanabel Noma syrup or other lettuce seed products during the past month Continuous consumption of Nejabal capsule or other Melissa officinalis products during the last month History of allergy to lettuce or its seeds or Melissa officinalis

Design outcomes

Primary

Measure	Time frame
Anxiety score in the questionnaire. Timepoint: Half an hour before the intervention (taking medicine), After the tooth extraction procedure. Method of measurement: Modified Dental Anxiety Scale for Dental Extraction Procedure questionnaire.;Heart rate. Timepoint: Half an hour before the intervention (taking medicine), After the tooth extraction procedure. Method of measurement: Pulse oximeter device.;Blood oxygen saturation percentage. Timepoint: Half an hour before the intervention (taking medicine), After the tooth extraction procedure. Method of measurement: Pulse oximeter device.	—

Measure

Time frame

Anxiety score in the questionnaire. Timepoint: Half an hour before the intervention (taking medicine), After the tooth extraction procedure. Method of measurement: Modified Dental Anxiety Scale for Dental Extraction Procedure questionnaire.;Heart rate. Timepoint: Half an hour before the intervention (taking medicine), After the tooth extraction procedure. Method of measurement: Pulse oximeter device.;Blood oxygen saturation percentage. Timepoint: Half an hour before the intervention (taking medicine), After the tooth extraction procedure. Method of measurement: Pulse oximeter device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Mazdak

Esfahan University of Medical Sciences

alimazdak@res.mui.ac.ir+98 31 3668 8138

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026