Evaluation of the effect of royal jelly on post extraction socket healing

Evaluation of the effect of royal jelly on post extraction socket healing ; A randomized triple blind clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221127056634N1

Enrollment

Registered

2023-01-23

Start date

2023-02-04

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post extraction socket healing.

Interventions

Intervention 1: Intervention group: In this group, after tooth extraction and washing the tooth socket with injectable sterile normal saline, pure royal jelly powder (prepared from the pharmaceutical

is mixed to a concentration of five percent in sterile normal saline (Sodium Chloride 0.9% for injection, Iranian Parenteral and Pharmaceutical Co. Tehran, Iran). Then the gelatamp smeared with this m

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: All patients who refer for extraction of non-impacted molar teeth At least 18 years old Without any systemic disease

Exclusion criteria

Exclusion criteria: History of the long-term use of non-steroidal anti-inflammatory drugs or corticosteroids or bisphosphonates or chemotherapy drugs or immunosuppressive drugs The need for antibiotic prophylaxis before tooth extraction Known allergy to honey or its products Continuous use of royal jelly in the last 6 months Severe untreated periodontal disease Being under dental treatment Compulsion to use any type of mouthwash or any type of medicine from the time of tooth extraction until ten days later Smoking Addiction to alcohol, drugs, medicine or a certain substance Acute infection or presence of pus in the tooth area Pregnancy

Design outcomes

Primary

Measure	Time frame
Wound size of tooth socket. Timepoint: Measurement of wound size at the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Using a caliper (ae JUYA instruments, Istanbul, Turkey).;Bleeding after palpation of the tooth socket. Timepoint: Examination of bleeding after palpation at the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visually.;The presence or absence of pus in the tooth socket. Timepoint: At the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visually.;Presence or absence of granulation tissue in the tooth socket. Timepoint: At the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visually.;Tissue color of the tooth socket. Timepoint: At the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visually.;Amount of pain. Timepoint: At the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visual Analogue Scale.	—

Measure

Time frame

Wound size of tooth socket. Timepoint: Measurement of wound size at the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Using a caliper (ae JUYA instruments, Istanbul, Turkey).;Bleeding after palpation of the tooth socket. Timepoint: Examination of bleeding after palpation at the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visually.;The presence or absence of pus in the tooth socket. Timepoint: At the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visually.;Presence or absence of granulation tissue in the tooth socket. Timepoint: At the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visually.;Tissue color of the tooth socket. Timepoint: At the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visually.;Amount of pain. Timepoint: At the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visual Analogue Scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Mazdak

Esfahan University of Medical Sciences

alimazdak@res.mui.ac.ir+98 31 3668 0048

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026