The effect of licorice administration on patients with rheumatoid arthritis

The effects of licorice supplementation on clinical symptoms and inflammatory markers in patients with active rheumatoid arthritis

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221127056629N1

Enrollment

Registered

2022-12-18

Start date

2022-12-22

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid Arthritis. Rheumatoid arthritis with rheumatoid factor

Interventions

Intervention 1: Intervention group: Rheumatoid arthritis patients who received capsules containing 0.5 mg of licorice prepared by Iran Daruk Company 3 times a day for 8 weeks. Intervention 2: Control

Eligibility

Sex/Gender

All

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients with joint rheumatism referring to Sirjan Faculty of Medical Sciences clinic Filling the consent form by patients

Exclusion criteria

Exclusion criteria: Heart, kidney or hypertension patients, history of heart attack, high blood lipids, abnormal kidney or liver function, use of non-steroidal anti-inflammatory drugs, use of vitamins and/or mineral supplements and drugs such as thyroid hormones, anti-hypertensive drugs Blood, contraceptives, diuretics and beta-blockers, as well as alcohol consumption, smoking, pregnancy and breastfeeding Other underlying diseases and also it should be mentioned that each person participating in the study will be excluded from the study in case of discontinuation of treatment or side effects caused by the consumption of licorice.

Design outcomes

Primary

Measure	Time frame
Disease severity. Timepoint: 0?90. Method of measurement: Disease activity score 28 ( DAS28).	—

Secondary

Measure	Time frame
Erythrocyte sed?mentation rate. Timepoint: 0?90. Method of measurement: Westergren method.;Intensity of pain. Timepoint: 0?90. Method of measurement: The patients will be asked to mark their pain level from their point of view on a ten-point scale.;CRP. Timepoint: 0,90. Method of measurement: Agglutination method.;TNF-a. Timepoint: 0,90. Method of measurement: Eliza method.;IL-6. Timepoint: 0,90. Method of measurement: Eliza method.;Systolic blood pressure. Timepoint: 0,90. Method of measurement: by barometer.;Diastolic blood pressure. Timepoint: 0,90. Method of measurement: by barometer.;AST. Timepoint: 0,90. Method of measurement: Colorimetric method and photometer.;Licorice. Timepoint: 0,90. Method of measurement: by scales.;Potassium. Timepoint: 0,90. Method of measurement: Flynn photometry method.;Fasting blood sugar. Timepoint: 0?90. Method of measurement: Colorimetric method and photometer.	—

Measure

Time frame

Erythrocyte sed?mentation rate. Timepoint: 0?90. Method of measurement: Westergren method.;Intensity of pain. Timepoint: 0?90. Method of measurement: The patients will be asked to mark their pain level from their point of view on a ten-point scale.;CRP. Timepoint: 0,90. Method of measurement: Agglutination method.;TNF-a. Timepoint: 0,90. Method of measurement: Eliza method.;IL-6. Timepoint: 0,90. Method of measurement: Eliza method.;Systolic blood pressure. Timepoint: 0,90. Method of measurement: by barometer.;Diastolic blood pressure. Timepoint: 0,90. Method of measurement: by barometer.;AST. Timepoint: 0,90. Method of measurement: Colorimetric method and photometer.;Licorice. Timepoint: 0,90. Method of measurement: by scales.;Potassium. Timepoint: 0,90. Method of measurement: Flynn photometry method.;Fasting blood sugar. Timepoint: 0?90. Method of measurement: Colorimetric method and photometer.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad amin serpoosh

sirjan school of medical science

aminsrps@gmail.com+98 34 4223 4513

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026