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Comparison of the safety and efficacy of labor induction with oral Misoprostol in different doses

Comparison of the safety and effectiveness of labor induction using 25 micrograms of oral Misoprostol versus 50 micrograms in pregnant women with premature rupture of membranes

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221123056587N1
Enrollment
400
Registered
2023-07-27
Start date
2021-03-21
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm Premature Rupture of Membrane. Preterm premature rupture of membranes, unspecified as to length of time between rupture and onset of labor

Interventions

Intervention 1: Pregnant women diagnosed with Preterm Premature Rupture of the Membrane (PPROM) were administered Ingestible 25 micrograms of Misoprostol every 2 hours up to 12 doses. Intervention 2:

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Pregnant women with premature rupture of membranes No history of cesarean delivery No Contraindication of natural labor No Contraindication to Misoprostol Cephalic presentation Parity less than 5 Bishop Score of less than 4 Singleton pregnancy Pregnant for 36 weeks or more

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Time Interval Between the beginning of Labour Induction and Occurrence of the Labour. Timepoint: Time Interval Between the beginning of Labour Induction and Occurrence of the Labour. Method of measurement: Timing.;Health of the newborn. Timepoint: Between minute one to minute five after the birth. Method of measurement: Apgar score.;Type of Labour. Timepoint: At the time of the birth. Method of measurement: Observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactErfaneh Ebadi

Iran University of Medical Sciences

Erfane91@gmail.com+98 26 3447 2205

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026