Investigating the effect of adding traditional medicine treatments (honey and frankincense extract) to common treatments on polyuria in patients with diabetes insipidus

Investigating the effect of adding traditional medicine treatments (honey and frankincense extract) to common treatments on hyperuria in patients with diabetes insipidus in the intensive care unit -a preliminary study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221121056570N1

Enrollment

Registered

2022-12-29

Start date

2023-02-20

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neurogenic diabetes insipidus due to brain diseases or head injury. Diabetes insipidus

Interventions

Intervention 1: Intervention group 1: a group of patients who, receive traditional medicine including honey and frankincense extract as gavage every 12 hours for 48 hours in addition to classical trea

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Hospitalization in the intensive care unit Having diagnostic criteria for diabetes insipidus Signing the informed consent form by the patient's family Establishment of enteral nutrition Not having drug interactions with the drugs received by the patient based on the opinion of traditional medicine pharmacist colleagues

Exclusion criteria

Exclusion criteria: Discontinuation of enteral feeding for any reason Death of the patient due to various causes Patient discharge Declaration of non-consent by the patient's family to continue the plan The occurrence of drug interactions with the drugs received by the patient based on the opinion of traditional medicine pharmacist colleagues

Design outcomes

Primary

Measure	Time frame
Patient's urine volume during 24-hour. Timepoint: 24-hour urine volume measurement at the beginning of the study (before the start of the intervention) and 24 and 48 and 72 hours after the administration of placebo, honey-frankincense or honey-ginger combination. Method of measurement: 24-hour urine volume measurement by graduated urine bags connected to the patient's Foley catheter daily (every 24 hours).	—

Measure

Time frame

Patient's urine volume during 24-hour. Timepoint: 24-hour urine volume measurement at the beginning of the study (before the start of the intervention) and 24 and 48 and 72 hours after the administration of placebo, honey-frankincense or honey-ginger combination. Method of measurement: 24-hour urine volume measurement by graduated urine bags connected to the patient's Foley catheter daily (every 24 hours).

—

Secondary

Measure	Time frame
Serum sodium level. Timepoint: Serum sodium level measurement at the beginning of the study (before the start of the intervention) and 24 and 48 and 72 hours after the administration of placebo, honey-frankincense or honey-ginger combination. Method of measurement: Laboratory measurement on blood sample by biochemistry autoanalyzer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohsen Savaie

Ahvaz University of Medical Sciences

drsavaie@gmail.com+98 61 3311 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026