Multiple sclerosis.
Conditions
Interventions
Intervention 1: The first intervention group: non-menopausal women receiving MitoQ supplement. MitoQ supplement is an advanced antioxidant made by MitoQ company in New Zealand. This supplement will b
Sponsors
Kerman University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Diagnosis of MS by a neurologist Being in remission (at least 2 months after the last relapse) EDSS score less than 6 No acute attacks within 30 Last day Continuing to take MS drugs Not taking medicine for fatigue No taking drugs
Exclusion criteria
Exclusion criteria: People with cardiovascular, liver and kidney diseases People with diabetes Having any skeletal-muscular disorders and obvious congenital anomalies Having obvious visual impairments Having certain diseases such as cancer People with mental disabilities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum estrogen levels. Timepoint: Estrogen hormone will be measured at the beginning of the study (before the intervention) and 60 days (two months) after the start of the supplement and exercise program. Method of measurement: ELISA KIT.;Serum progesterone levels. Timepoint: Progesterone hormone will be measured at the beginning of the study (before the start of the intervention) and 60 days (two months) after the start of the supplement and exercise program. Method of measurement: ELISA KIT.;Serum levels of reactive oxygen species (ROS). Timepoint: The measurement of ROS will be at the beginning of the study (before the start of the intervention) and 60 days (two months) after the start of the supplement and exercise program. Method of measurement: Eliza kit (spectroscopy).;Serum level of total antioxidant capacity (TAC). Timepoint: The measurement of TAC will be at the beginning of the study (before the start of the intervention) and 60 days (two months) after the start of the supplement and exercise program. Method of measurement: Eliza kit (spectroscopy).;Serum level of glutathione peroxidase (GPx). Timepoint: GPx will be measured at the beginning of the study (before the start of the intervention) and 60 days (two months) after the start of the supplement and exercise program. Method of measurement: Eliza kit (spectroscopy).;Malondialdehyde (MDA) serum level. Timepoint: The measurement of MDA will be at the beginning of the study (before the start of the intervention) and 60 days (two months) after the start of the supplement and exercise program. Method of measurement: Eliza kit (spectroscopy).;MicroRNA gene expression (miR-146a). Timepoint: The measurement of miR-146a will be at the beginning of the study (before the start of the intervention) and 60 days (two months) after the start of the supplement and exercise program. Method of measurement: Real time PCR.;MicroRNA gene expression (miR-223). Timepoint: The measurement of miR-223 will be at the beginning | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAtena Alifarsangi
Kerman University of Medical Sciences
Outcome results
None listed