Migraine. Migraine
Conditions
Interventions
Intervention 1: Intervention group: Magnesium oxide 10 mg/kg in 1 or 2 divided dose for 3 months should be used. Generic Magnesium Oxide 250 mg tablets from Jalinus pharmaceutical company are used. pa
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: Age from 6 to 18 years old Weight less than 90 Kg Diagnosed as migraine according to IHSC-3 criteria At least 4 migraine attacks in month or 8 days-of-headache during at least 1 month ago
Exclusion criteria
Exclusion criteria: Coexistence of another type of headache Migrainous headache in at least 15 days per month Using analgesic medications in at least 15 days per month Pregnancy or intention of pregnancy History of epilepsy or other neurological comorbidities Mental retardation defined as IQ<70 Dependency or addiction to pharmaceutical or illicit drugs Magnesium administration contraindications Renal failure History of renal stone Propranolol administration contraindications Cardiac conduction block Bradycardia History of asthma History of hypersensitivity reaction to propranolol Diabetes mellitus Liver insufficiency Myasthenia gravis Psoriasis History of using migraine prophylaxis medications in the past month History of using magnesium supplements in the past month History of psychiatric disorders including depression, mood disorders, anxiety disorders or psychotic disorders History of using anti-depressants, anti-psychotics, mood stabilizers or sedatives Anticipation of patient's poor medication compliance Illiteracy of the patient and family and, inability of filling the diary
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of migraine attacks per month. Timepoint: At the beginning; then, 4 weeks later; then, 12 weeks after the initiation. Method of measurement: Direct asking of the patient in the first visit; then, using migraine diary in the following visits. | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of pain during migraine attacks. Timepoint: First visit; 4 weeks later; 12 weeks later. Method of measurement: Wong-baker scale.;Average duration of migraine attacks per month. Timepoint: First visit; 4 weeks later; 12 weeks later. Method of measurement: direct asking and migraine diary.;Amount of analgesic medications used. Timepoint: First visit; 4 weeks later; 12 weeks later. Method of measurement: direct asking and migraine diary. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactPegah Katibeh
Shiraz University of Medical Sciences
Outcome results
None listed