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effect of aprepitant on post-operation nausea vomiting of cholecystectomy surgery

Camparison of the effect of ondansetron and placebo versus ondansetron and aprepitant on post-operation nausea and vomitiing of cholecystectomy surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221110056459N1
Enrollment
60
Registered
2023-09-21
Start date
2023-03-21
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Nausea. Condition 2: vomiting. Nausea Vomiting

Interventions

Intervention 1: Intervention group: Aperpitant capsule 80 mg is prescribed one hour before the operation, and at the same time as the anti-nausea drug ondansetron 4 mg is administered intravenously. I

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: patients with ASA health scale of 1 or 2 patients who are candidated for cholecystectomy surgery

Exclusion criteria

Exclusion criteria: patients with ASA health scale of 3, 4 or 5 patients with other anesthesia methods patients with any systemic diseases such as diabetes, asthma, cardiovascular diseases, gastroesophageal reflux, severe obesity, BMI > 30, hepatorenal diseases, neuromuscular diseases, psychiatric illnesses, alcoholic patients, drug abusers, smokers pregnant or lactating patients patients presented with acute cholecystitis

Design outcomes

Primary

MeasureTime frame
The degree of nausea. Timepoint: 6 and 24 hour post-operation. Method of measurement: VAS criteria.;Vomiting. Timepoint: 6 and 24 hour post-operation. Method of measurement: if vomiting happen or not.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNasser Malekpour Alamdari

Shahid Beheshti University of Medical Sciences

nassermalekpour@sbmu.ac.ir+98 21 2207 4087

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026