Evaluating the effect of celecoxib in comparison with acetaminophen on orthodontic pain management

Evaluating the effect of celecoxib in comparison with acetaminophen on pain management after insertion of first orthodontic wire: a randomized, double-blind, controlled trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221109056454N1

Enrollment

Registered

2023-11-21

Start date

2023-11-22

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain after placing the first orthodontic wire. Encounter for fitting and adjustment of orthodontic device

Interventions

Intervention 1: Intervention group: The group that was prescribed celecoxib 200 mg 1 hour before and 6 hours after receiving the orthodontic wire. Intervention 2: Intervention group: The group that wa

Eligibility

Sex/Gender

All

Age

12 Years to 30 Years

Inclusion criteria

Inclusion criteria: The patient's age is between 12 and 30 years The treatment plan for orthodontic patients should be fixed without tooth extraction. According to little's irregularity index, they should have a moderate rating. Orthodontic treatment should start with the lower jaw.

Exclusion criteria

Exclusion criteria: Taking antibiotics and painkillers before orthodontic treatment Pregnant and lactating women Patients with history of allergy to celecoxib or acetaminophen Patients with a history of gastrointestinal or kidney ulcer and liver or cardiovascular failure History of drug addiction Not having written informed consent to participate in the study Patients with periodontal disease

Design outcomes

Primary

Measure	Time frame
Overall pain score. Timepoint: 2 hours after wire placement, 6 hours after that, the first night of wire placement, 24 hours after the start, and finally on the second, third, and seventh day. Method of measurement: The patient's score on the severity of orthodontic pain in the general state with the VAS index.;Pain score in chewing mode. Timepoint: 2 hours after wire placement, 6 hours after that, the first night of wire placement, 24 hours after the start, and finally on the second, third, and seventh day. Method of measurement: Patient's score of orthodontic pain severity in chewing state with VAS index.;Pain score in biting position. Timepoint: 2 hours after wire placement, 6 hours after that, the first night of wire placement, 24 hours after the start, and finally on the second, third, and seventh day. Method of measurement: Patient score of orthodontic pain severity in biting state with VAS index.	—

Measure

Time frame

Overall pain score. Timepoint: 2 hours after wire placement, 6 hours after that, the first night of wire placement, 24 hours after the start, and finally on the second, third, and seventh day. Method of measurement: The patient's score on the severity of orthodontic pain in the general state with the VAS index.;Pain score in chewing mode. Timepoint: 2 hours after wire placement, 6 hours after that, the first night of wire placement, 24 hours after the start, and finally on the second, third, and seventh day. Method of measurement: Patient's score of orthodontic pain severity in chewing state with VAS index.;Pain score in biting position. Timepoint: 2 hours after wire placement, 6 hours after that, the first night of wire placement, 24 hours after the start, and finally on the second, third, and seventh day. Method of measurement: Patient score of orthodontic pain severity in biting state with VAS index.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAtefeh Saffar Shahroudi

Tehran University of Medical Sciences

a-shahroudi@tums.ac.ir+98 21 4426 9453

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026