Brain Trauma. Diffuse traumatic brain injury
Conditions
Interventions
Intervention 1: Intervention group: They receive 1 gram of acetazolamide in oral form every 24 hours, which will continue for 5-7 days. Intervention 2: Control group: They receive 100 mg topiramate or
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patient consent to enter the study The patient's non-use of Tricyclic Antidepressants and carbonic anhydrase inhibitor in order to prevent drug interactions.
Exclusion criteria
Exclusion criteria: Patients who develop meningitis and brain abscess Patients with severe electrolyte disturbances Patients who do not respond to treatment and have to use brain surgery Patients who did not respond to drug therapy after one week and another intervention should be performed on them Failure to visit the patient for follow-up Kidney and liver patients who are suffering from a specific disease based on the diagnosis of a specialist and are listed in the patient's medical record
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebrospinal fluid leakage. Timepoint: Patients are evaluated weekly using a checklist and up to three months after discharge from the hospital. Method of measurement: Checklist and measurement of GCS. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehdi Mahmoodkhani
Esfahan University of Medical Sciences
Outcome results
None listed