Severe traumatic brain injury. Diffuse traumatic brain injury
Conditions
Interventions
Intervention 1: Intervention group: Dalfampridine receptor (this drug is prescribed to the patient at a dose of 10 mg twice a day (every 12 hours)). Intervention 2: Control group: Placebo.
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Being between 18 and 65 years old More than a month has passed since the beginning of the trauma Having a level of consciousness less than 9 Not having a neurological or psychological disease before the trauma Presence of spasticity in the upper or lower limbs according to the Ashworth criteria
Exclusion criteria
Exclusion criteria: Lack of consent of the patient's companion to enter the study Having a level of consciousness higher than 9 at the beginning of the trauma History of seizures, kidney and liver diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of muscle spasms. Timepoint: Before treatment, three and six months after the intervention. Method of measurement: Ashworth scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactEsfahan University of Medical Sciences
Esfahan University of Medical Sciences
Outcome results
None listed