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Nasal dexmedetomidine and oral chloral hydrate on sedation in children

A comparative study of the effect of nasal dexmedetomidine and oral chloral hydrate on sedation of children during MRI

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221108056446N15
Enrollment
70
Registered
2025-02-09
Start date
2025-02-19
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedation. Failed moderate sedation during procedure

Interventions

Intervention 1: Intervention group: Chloral hydrate will be administered orally. Children in this group will receive 5% chloral hydrate syrup at a dose of 50-100 micrograms/kg orally 10 minutes before

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Months to 10 Years

Inclusion criteria

Inclusion criteria: Children who are candidates for MRI and require sedation for any reason. The child's parents must consent to participate in the study.

Exclusion criteria

Exclusion criteria: Patients with a history of respiratory diseases Stomach ulcers or liver disease Treatment with drugs that interact with chloral hydrate or dexmedetomidine The presence of a specific underlying condition that affects the interpretation of goals such as duration of sedation Any previous allergic reaction to chloral hydrate or dexmedetomidine

Design outcomes

Primary

MeasureTime frame
Sedation. Timepoint: Patients were examined every 5 minutes and then every 10 minutes for up to an hour. Method of measurement: The AVPU scale is used to assess a child's level of alertness and sleepiness.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohamadreza Ghazavi

Esfahan University of Medical Sciences

ghazavi8147@gmail.com+98 31 3386 6266

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026