Comparison between L-arginine and aspirin and aspirin alone in preventing preeclampsia in high-risk pregnant women.

Comparison of the Effectiveness of l_arginine plus aspirin with aspirin alone in preventing adverse outcomes in pregnant women at high risk of preeclampsia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221108056440N1

Enrollment

Registered

2022-11-27

Start date

2022-11-22

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Preeclampsia. Condition 2: Diabetes Mellitus. Condition 3: Hypertension. Pre-eclampsia Diabetes mellitus in pregnancy, childbirth, and the puerperium Essential (primary) hypertension

Interventions

Intervention 1: Intervention group: L-arginine 1000 mg along with aspirin 80 mg will be prescribed once a day for pregnant women who are among the high-risk group for preeclampsia, . Intervention 2:

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Pregnant women who are at high risk for preeclampsia Pregnant women with a gestational age between 14 and 28 weeks of pregnancy Previous history of pre-eclampsia in the individual or first degree relatives of the individual's sister or mother Women with a history of chronic hypertension Body mass index greater than 30 Multiple pregnancy Lipid disorders

Exclusion criteria

Exclusion criteria: Drug sensitivity to L-arginine Drug sensitivity to aspirin

Design outcomes

Primary

Measure	Time frame
Blood Pressure. Timepoint: During the first appointments and at each pregnancy care visit (for visits during pregnancy, it is once a month from the first week to 28 weeks, and every two weeks from 28 to 36 weeks and then weekly examination until the end of pregnancy). Method of measurement: The percentage of people with blood pressure above 90.140 mm Hg.;Preeclampsia. Timepoint: From the 20th week of pregnancy during any pregnancy care as discussed above or if there are any signs and symptoms of preeclampsia from the 20th week onwards. Method of measurement: Checking blood pressure and other signs and symptoms of pre-eclampsia, including headache, blurred vision, chest pain or laboratory disorders such as thrombocytopenia or increased liver enzymes or increased creatinine.	—

Measure

Time frame

Blood Pressure. Timepoint: During the first appointments and at each pregnancy care visit (for visits during pregnancy, it is once a month from the first week to 28 weeks, and every two weeks from 28 to 36 weeks and then weekly examination until the end of pregnancy). Method of measurement: The percentage of people with blood pressure above 90.140 mm Hg.;Preeclampsia. Timepoint: From the 20th week of pregnancy during any pregnancy care as discussed above or if there are any signs and symptoms of preeclampsia from the 20th week onwards. Method of measurement: Checking blood pressure and other signs and symptoms of pre-eclampsia, including headache, blurred vision, chest pain or laboratory disorders such as thrombocytopenia or increased liver enzymes or increased creatinine.

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Secondary

Measure	Time frame
Termination of pregnancy (term or pre-term). Timepoint: At the end of pregnancy. Method of measurement: With the birth of a baby and during childbirth.;IUGR. Timepoint: During pregnancy care, especially during the 28th till 32nd weeks and at the time of birth. Method of measurement: Measurement of fetal weight and growth during pregnancy and birth weight.;Pregnancy complication. Timepoint: During pregnancy and childbirth. Method of measurement: Examination in terms of the amount of bleeding, meconium, decollement, stillbirth, preterm labour.	—

Measure

Time frame

Termination of pregnancy (term or pre-term). Timepoint: At the end of pregnancy. Method of measurement: With the birth of a baby and during childbirth.;IUGR. Timepoint: During pregnancy care, especially during the 28th till 32nd weeks and at the time of birth. Method of measurement: Measurement of fetal weight and growth during pregnancy and birth weight.;Pregnancy complication. Timepoint: During pregnancy and childbirth. Method of measurement: Examination in terms of the amount of bleeding, meconium, decollement, stillbirth, preterm labour.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Akbary

Kashan University of Medical Sciences

akbari1350@yahoo.com+98 31 5550021

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026