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Evaluation of the effect of Kefir produced from cow's milk on the treatment process and immune response of patients with Corona virus 2019 (COVID-19

Evaluation of the effect of Kefir produced from cow's milk on the clinical outcomes and immune response of patients with COVID-19; a randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221106056423N1
Enrollment
100
Registered
2022-11-27
Start date
2022-11-22
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. Coronavirus infection, unspecified

Interventions

Intervention 1: Intervention group: Giving 250 cc of kefir (twice a day) along with following the hospital diet for 14 days. Intervention 2: Control group: No intervention with kefir and only followin

Sponsors

Artesh University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Positive PCR-test confirming COVID-19 infection Having a moderate or severe level of the disease ICU patients (provided that there is no restriction on the consumption of certain food substances) Age between 20-60 years Administering 2 doses of Sinopharm vaccine Absence of food allergies

Exclusion criteria

Exclusion criteria: Pregnancy or lactating Use of anti-coagulant drugs No infection with the Covid-19 virus

Design outcomes

Primary

MeasureTime frame
Fever. Timepoint: At the baseline and end of the intervention. Method of measurement: Thermometer.;C-Reactive Protein. Timepoint: At the baseline and end of the intervention. Method of measurement: kit (Bionik, Iran) with the BT3500 (Biotecnica Instruments SpA -Italy) auto-analyzer.;Erythrocyte Sedimentation Rate (ESR). Timepoint: At the baseline and end of the intervention. Method of measurement: Westergren Method.;Dyspnea. Timepoint: At the baseline and end of the intervention. Method of measurement: Clinical examintation.

Secondary

MeasureTime frame
Gastrointestinal symptoms. Timepoint: At the baseline and the end of the intervention. Method of measurement: Clinical examination.;WBC. Timepoint: At the baseline and the end of the intervention. Method of measurement: Sysmex K-1000 Hematology Analyzer.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRamin Gooruee

Artesh University of Medical Sciences

ramingooruee@gmail.com+98 21 4382 2952

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026