vitiligo. Vitiligo
Conditions
Interventions
Intervention 1: Control group: topical 5-Fluorouracil. In the 5-FU topical treatment group, patients will use 5-Fluorouracil topically on the lesions twice daily. The medicine will be in topical form
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: No new lesions and no progression of existing lesions for at least 2 years
Exclusion criteria
Exclusion criteria: pregnancy allergy to 5- Fluorouracil Patients with infectious patches, vitiligo spots on the mucous membrane, Kubner's phenomenon, tendency to keloid or hypertrophic scars. Coagulation disorders Other uncontrolled systemic diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Discoloration of vitiligo spots. Timepoint: Evaluation of lesions in both groups will continue every month until three months after the end of the interventions. Method of measurement: Discoloration of vitiligo patches will be graded as 1 (no response, milky white color still present, or erythematous color), 2 (opaque white color change), 3 (light brown color change), and 4 (normal skin color). Evaluation will also be done using the pigment score, which compares baseline vitiligo status and percent improvement as follows: 0, no response, 75%, excellent response. | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment complications. Timepoint: Evaluation of lesions in both groups will continue every month until three months after the end of the interventions. Method of measurement: Examination and history taking by the doctor. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyyede Haleh Sadroleslami
Tabriz University of Medical Sciences
Outcome results
None listed