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The Effect of Ascorbic Acid on the blood loss in Total Knee Arthroplasty

Evaluation the Effect of Ascorbic Acid compared to normal saline on the hidden blood loss in total knee arthroplasty

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221104056393N1
Enrollment
100
Registered
2023-06-27
Start date
2023-06-18
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total Knee Arthroplasty. Osteoarthritis of knee, unspecified

Interventions

Intervention 1: Control group: The patients in the control group will receive only normal saline. Intervention 2: Intervention group: The patients in the intervention group will receive the first asco

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Candidates of total knee arthroplasty patients who provide written informed consent to be included in this study

Exclusion criteria

Exclusion criteria: history of thromboembolic events like deep vein thrombosis or pulmonary embolism history of cardiovascular disease like myocardial infarction or atrial fibrillation being in pregnancy or in the lactation period drug abusers or alcoholics severe renal dysfunction severe infection the preoperative hemoglobin less than 10 g/dL diagnosis of inflammatory arthritis like rheumatoid arthritis, pigmented villonodular synovitis and etc clotting disorders including abnormal PT, PTT or INR

Design outcomes

Primary

MeasureTime frame
Total blood loss. Timepoint: Before intervention, 24h after intervention. Method of measurement: amount of Hemoglobin drop.

Secondary

MeasureTime frame
Transfusion rate. Timepoint: Before the intervention, 24h after the intervention. Method of measurement: number of units of blood transfused.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Morteza Kazemi

Shahid Beheshti University of Medical Sciences

kazemimort@gmail.com+98 21 2200 1072

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026