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"Effect of Topical Metronidazole in treatment of chronic fissure"

Comparison of the Effectiveness of Metronidazole and Diltiazem Gel in Pain Control in Chronic Anal Fissure Patients

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221102056377N1
Enrollment
54
Registered
2023-01-18
Start date
2023-02-04
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Anal Fissure. Chronic anal fissure

Interventions

Intervention 1: Intervention group: In the intervention group, topical Metronidazole 0.75% (Pars Daro Pharmaceutical Company) will be used 3 times a day for 14 days. Intervention 2: Control group: In

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: All individuals with anal fissures for more than 6 weeks

Exclusion criteria

Exclusion criteria: Suffering from other colorectal diseases The person is unable to participate in follow-up visits Duration of symptoms less than 6 weeks

Design outcomes

Primary

MeasureTime frame
Determination of pain intensity in patients with chronic anal fissure treated with Metronidazole gel and diltiazem. Timepoint: Determination of pain intensity in patients with chronic anal fissure at the beginning of the study and 10, 21, 28 days after starting Metronidazole. Method of measurement: Examination of Anus; Use of Visual Analogue Scale.;Determining the duration of pain in patients with chronic anal fissure treated with Metronidazole gel and Diltiazem. Timepoint: Determining the duration of pain in patients with chronic anal fissure at the beginning of the study and 10, 21, 28 days after starting Metronidazole. Method of measurement: Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Amir Sadeghi

Shahid Beheshti University of Medical Sciences

amirsadeghi@yahoo.com+98 21 2243 2560

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026