Effect of Sublingual Atropine on Sialorrhea Induced by Clozapine

Effect of Sublingual Atropine on Sialorrhea Induced by Clozapine in Patients with Schizophrenia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221101056373N1

Enrollment

Registered

2022-11-12

Start date

2022-12-22

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Clozapin induced sialorrhea.

Interventions

Intervention 1: Intervention group: After washing and cleaning the mouth, for 4 weeks and every night 1% hour before sleeping, two drops of atropine sulfate will be administered under the tongue. Inte

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age 18 to 60 years Diagnosed schizophrenia Current use of Clozapine for treatment Presence of drooling

Exclusion criteria

Exclusion criteria: Pregnancy and breastfeeding Cardiovascular problems (arrhythmia, blood pressure, etc.) History of taking other anticholinergics

Design outcomes

Primary

Measure	Time frame
Sialorrhea. Timepoint: For 4 weeks and every night 1 hour before sleep. Method of measurement: Visual analogue scale and Drooling Rating Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNarges Shams alizadeh

Sanandaj University of Medical Sciences

n.shamsalizadeh@muk.ac.ir+98 87 3366 0026

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026