Knee osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: Patients with primary OA of the knee, who after checking the entry and exit criteria and signing the consent form, were randomly injected with temperature-dependent
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: Primary one-sided osteoarthritis of the knee that has been at least 6 months since it became symptomatic (painful) and aggravated by weight bearing and has not responded properly to conservative treatment. Radiographic arthrosis stage 1, 2 and 3 of Kellgren Lawrence classification (KLS) Signing the consent form and complete and voluntary willingness to participate in the study
Exclusion criteria
Exclusion criteria: Any history of trauma (fracture), surgery and tumor in the knee and lower limb of the same side Clinically obvious alignment disorder Any history of invasive procedure, injection or infection in the desired knee during the last 6 months Any blood disorder History or history of autoimmune disease or being treated with immunosuppressors and non-removable corticosteroids Patients with secondary osteoarthritis Proven liver and kidney disorders Irrevocable consumption of oral or topical painkillers Cognitive impairments and the inability to walk without a walker or the help of others CVA and similar problemsInsulin-dependent diabetic patients Patients with spine disorders and radicular pain to the lower limbs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of the parameters related to the immune system including the level of IL-10, TNF-a, IL-6, TGF-beta1). Timepoint: It will be performed at the beginning, second week and fourth weeks. Method of measurement: Commercial lab kits.;Liver tests including the serum level of ALT and AST. Timepoint: It will be performed at the beginning, second week and fourth weeks. Method of measurement: Commercial kits.;BUN and creatinine. Timepoint: It will be performed at the beginning, second week and fourth weeks. Method of measurement: Commercial kits.;Range of motion of the joint (goniometer and degree). Timepoint: It will be performed at the beginning, second week and fourth weeks. Method of measurement: goniometer and degree.;The sitting and standing test (number). Timepoint: It will be performed at the beginning, second week and fourth weeks. Method of measurement: Physical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMona Alibolandi
Mashhad University of Medical Sciences
Outcome results
None listed