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Comparison of microneedling with Tranexamic acid and PRP in treatment of Melasma

Evaluation of the effectiveness of microneedling with Tranexamic acid in comparison with microneedling with PRP in the treatment of melasma

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221025056287N1
Enrollment
23
Registered
2022-12-09
Start date
2022-10-31
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Melasma. Other disorders of pigmentation

Interventions

Intervention 1: Intervention group 1: performing Microneedling to a depth of 1.5 to 2 mm of the skin using a 36-needle disposable cartridge with 200 mg Tranexamic acid in 3 times with an interval of

Sponsors

Ahvaz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 18-50 years old women with Melasma Symmetrical and bilateral facial Melasma

Exclusion criteria

Exclusion criteria: Pregnant women Breastfeeding mothers Use of anticoagulants and anticonvulsants Being allergic to the study drugs and topical lidocaine History of Melasma treatment during the past month Active Herpes simplex lesions on the face Facial warts Any history of coagulation disorders and thrombotic problems

Design outcomes

Primary

MeasureTime frame
Melasma measuring index (MASI SCORE). Timepoint: At the beginning of the study, the second and third sessions and 3 weeks after the completion of treatment sessions. Method of measurement: Taking photo of the face with camera.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHavva Hajati

Ahvaz University of Medical Sciences

hajati.h@ajums.ac.ir009832921873

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026