Evaluation of probiotics effect on quality of life and seizure attacks in patients with refractory epilepsy

Evaluation of probiotics effect on quality of life and seizure attacks in patients with refractory epilepsy in pediatric neurology clinics of Urmia University of Medical Sciences

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221024056286N1

Enrollment

Registered

2022-12-21

Start date

2023-01-21

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

epilepsy. Epilepsy and recurrent seizures

Interventions

Intervention group: Administration of Reuteflor probiotic which contains 300 miligram lyophilized live friendly bacteria , Lactobacillus reuteri , once per day dose that dissolve in cool water or food

Eligibility

Sex/Gender

All

Age

3 Years to 18 Years

Inclusion criteria

Inclusion criteria: patients with refractory epilepsy

Exclusion criteria

Exclusion criteria: Cause serious complications following drug use Dissatisfaction with continuing the study Non-epileptic seizures History of status epilepticus in the last 12 months Change in dose and type of antiepileptic drugs in the last 30 days Probiotic consumption in the last 30 days Chronic GI diseases, kidney or liver failure lactose intolerance Life expectancy less than 1 year Presence of progressive neurodegenerative disease Presence of any psychiatric disorder

Design outcomes

Primary

Measure	Time frame
Quality of life score in Quality of Life in Childhood Epilepsy Questionnaire version 55. Timepoint: 3 months before and 3 month later. Method of measurement: Quality of life score in Quality of Life in Childhood Epilepsy Questionnaire version 55.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParisa Alaie

Oroumia University of Medical Sciences

hamed.nodet@gmail.com+98 44 3343 8795

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026