Obstructive sleep apnea. Obstructive sleep apnea (adult) (pediatric)
Conditions
Interventions
Intervention 1: Intervention group: Thirty participants will randomly assign to the melatonin group. Patients will receive 3 mg melatonin (time release) orally in a single dose or placebo, 1 h before
Sponsors
NIMAD
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 75 years Diagnosis of OSA [apnea-hypopnea index (AHI) =?15] BP =?180/110 mmHg
Exclusion criteria
Exclusion criteria: Patients who have been hospitalized for cardiac or respiratory exacerbations less than 6 weeks prior to recruiting Those with autonomic nervous system diseases or endocrine disorders which might influence BP BP =?180/110 mmHg Those unwilling to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic and diastolic BP, serum ACE level and cortisol. Timepoint: Before and one month after the intervention. Method of measurement: Using polysomnography and laboratory evaluation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Rasoul Ghadami
Kermanshah University of Medical Sciences
Outcome results
None listed