Dependence on opioids. withdrawal symptoms, Craving, Anxiety, Opiate Addicted men, Fertility
Conditions
Interventions
Intervention 1: Control group: A sample of 20 people will be the control group, who will receive oxytocin spray placebo and zinc sulfate placebo for fourteen days. Intervention 2: Intervention group:
Sponsors
Zanjan University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: According to the DSM-5, a person must qualify for opioid dependence The patient is being treated with methadone maintenance and is stabilized on it The patient must give written consent to participate in the intervention People participating in the intervention must be male and between 20 and 50 years old and must be literate
Exclusion criteria
Exclusion criteria: Having suicidal thoughts History of any kind of blood disease, glandular disease, heart disease, lung disease, kidney disease, drug sensitivity, diabetes People with major depressive disorder People receiving glucocorticoid treatment in the last month People receiving serotonergic therapy or other antidepressants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxytocin. Timepoint: Before and after the intervention and two months later for follow-up. Method of measurement: Hormonology.;Zinc. Timepoint: Before and after the intervention and two months later for follow-up. Method of measurement: Measurement of zinc level in blood. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Opiate Withdrawal Scale. Timepoint: Before and after the intervention and two months later for follow-up. Method of measurement: Through the checklist for withdrawal symptoms:For each item, circle the number that best describes the patient' s signs or symptom.;Craving. Timepoint: Before and after the intervention and two months later for follow-up. Method of measurement: Desire for Drug Questionnaire.;Stress. Timepoint: Before and after the intervention and two months later for follow-up. Method of measurement: Depression- Anxiety- Stress Scale.;Anxiety. Timepoint: Before and after the intervention and two months later for follow-up. Method of measurement: Depression- Anxiety- Stress Scale.;Depression. Timepoint: Before and after the intervention and two months later for follow-up. Method of measurement: Depression- Anxiety- Stress Scale.;Testosterone. Timepoint: Before and after the intervention and two months later for follow-up. Method of measurement: Hormonology.;Spermogram. Timepoint: Before and after the intervention and two months later for follow-up. Method of measurement: In the Spermogram, two characteristics of semen are considered: 1- Macroscopic characteristics 2- Microscopic characteristics Macroscopic characteristics of semen including color, transparency, concentration of hydrogen ions or pH, volume, duration of closeness, fluidity and viscosity are examined. take The microscopic characteristics of semen include motility, sperm count, viability, sperm morphology, white and red blood cells, and the quality of fructose levels in semen. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactEhsan Sabouri
Zanjan University of Medical Sciences
Outcome results
None listed